2025 Enlist Product Use Guide_Web

ENLIST ® WEED CONTROL SYSTEM

2025 PRODUCT USE GUIDE ENLIST ® HERBICIDES — USED WITH ENLIST E3 ® SOYBEANS, ENLIST CORN AND ENLIST COTTON

What you’ll find inside: The Enlist ® weed control system.. . . . . . . . . . . . 3 Enlist ® Ahead...............................5 Enlist ® herbicides............................6 Cornerstone of a program approach.. . . . . . 7 Herbicide partners from Corteva Agriscience. . . . . . . . . . . . . . . . . . . . . . 9 The TruChoice ® offer..................... 12 Glufosinate herbicides.. . . . . . . . . . . . . . . . . . 13 Tank-mixing with Enlist ® herbicides.. . . . . . . 14 Nozzles.................................. 16 Fieldplanning........................... 23

Runoffmitigation........................ 28 Equipmentcleanout.................... 29 Application summary. . . . . . . . . . . . . . . . . . . .30 Crops with the Enlist ® trait................. 32 Enlist E3 ® soybeans...................... 32 Enlist ® corn.............................. 33 Enlist ® cotton........................... 34 Help prevent herbicide resistance development with the Enlist ® system.. . . . . . 35 Crop response and pollinator protection.. . . 37 Further stewardship info.. . . . . . . . . . . . . . . . . . 39

This reference guide is not intended as a substitute for the product label for product(s) referenced herein. Always read and follow all label directions and precautions for use when using any pesticide alone or in tank-mix combination. Failure to follow the label, including any supplemental label precautions, is considered a misuse under federal law. To find product labels and additional resources about the Enlist ® weed control system, visit Enlist.com or scan the QR code below:

The Enlist ® weed control system

The Enlist ® weed control system is here for the long haul, and here’s why: It’s based in science and backed by stewardship. This unrivaled system starts with Enlist ® herbicide-tolerant traits that enable the use of our powerful Enlist ® herbicides. The Enlist ® Ahead management resource provides tools and training to make sure you get the most from the system.

HERBICIDE TOLERANCES

Bt CORN PRODUCTS WITH ENLIST ® TRAIT

ENLIST ® W3FE COTTON ENLIST ® W3E1 COTTON

ENLIST E3 ® SOYBEANS

2,4-D choline

Glufosinate

Glufosinate 1

Glufosinate

Glyphosate

FOP herbicides 2

Glyphosate

1 Non- Bt corn products with the Enlist ® trait may not contain glufosinate tolerance. See bag tag to verify herbicide tolerance. 2 Not all FOP herbicides are labeled for use in Bt corn products with the Enlist ® trait. Before use, review the product label to ensure the product is labeled for use on Bt corn with the Enlist trait.

Straight-goods 2,4-D choline with additional tank-mix flexibility

Convenient proprietary blend of 2,4-D choline and glyphosate

Enlist One ® herbicide is a straight-goods 2,4-D choline product with Colex-D ® technology that provides additional tank- mix flexibility with products listed on EnlistTankMix.com, such as glufosinate herbicides, glyphosate herbicides, residual herbicides, fungicides and insecticides. Enlist Duo ® herbicide with Colex-D technology combines the proven performance of 2,4-D choline and glyphosate in a convenient, proprietary blend. Following burndown, Enlist Duo ® and Enlist One ® herbicides with Colex-D ® technology are the only herbicides containing 2,4-D that are authorized for preemergence and postemergence use with Enlist ® crops. Consult Enlist ® herbicide labels for weed species controlled. Enlist Duo and Enlist One herbicides are not registered for use or sale in all states and counties; are not registered in AK, CA, CT, HI, ID, MA, ME, MT, NH, NV, OR, RI, UT, VT, WA and WY; and have additional subcounty restrictions in AL, GA, TN and TX, while existing county restrictions still remain in FL. All users must check “Bulletins Live! Two” no earlier than six months before using Enlist One or Enlist Duo herbicide. To obtain “Bulletins,” consult www.epa.gov/espp/, call 844-447-3813, or email espp@epa.gov. You must use the “Bulletin” valid for the month and state and county in which Enlist One or Enlist Duo herbicide are being applied. Contact your state pesticide regulatory agency if you have questions about the registration status of Enlist ® herbicides in your area. ALWAYS READ AND FOLLOW PESTICIDE LABEL DIRECTIONS. IT IS A VIOLATION OF FEDERAL AND STATE LAW TO USE ANY PESTICIDE PRODUCT OTHER THAN IN ACCORDANCE WITH ITS LABELING. ONLY USE FORMULATIONS THAT ARE SPECIFICALLY LABELED FOR SUCH USE IN THE STATE OF APPLICATION. USE OF PESTICIDE PRODUCTS, INCLUDING, WITHOUT LIMITATION, 2,4-D-CONTAINING PRODUCTS NOT AUTHORIZED FOR USE WITH ENLIST CROPS, MAY RESULT IN OFF-TARGET DAMAGE TO SENSITIVE CROPS/AREAS AND/OR SUSCEPTIBLE PLANTS, IN ADDITION TO CIVIL AND/OR CRIMINAL PENALTIES. Additional product-specific stewardship requirements for Enlist crops, including the Enlist Product Use Guide, can be found at TraitStewardship.com. Always read and follow label directions.

States where Enlist Duo ® and Enlist One ® herbicides are registered

REGISTERED STATES

Get the best results with the Enlist ® Ahead management resource Enlist ® Ahead is a management resource that helps you get the best results from the Enlist ® weed control system while protecting the herbicide-tolerant technology for the future, helping you: • Make on-target applications on your crops. • Select and use different sites of action in the same growing season. • Mitigate herbicide resistance and prevent new resistance development in your fields (Learn more on this topic on Page 35). As part of Enlist Ahead, you can: • Download the Enlist ® Ahead app for readily accessible information on your iOS device. • Visit Enlist.com for an overview of the Enlist weed control system, an online training module and other technical information. • Visit EnlistTankMix.com for qualified tank-mix partner listings. • Get support from your local Corteva Agriscience crop protection territory manager and Enlist ® field specialist. Following the best practices presented in Enlist Ahead will help you achieve optimum results and sustain the long-term performance of the Enlist ® weed control system. Growers of Enlist ® crops must read and follow the refuge and Insect Resistance Management (IRM) requirements in Product Use Guides found at TraitStewardship.com.

Take control of tough weeds with Enlist Duo ® and Enlist One ® herbicides

Use Enlist ® herbicides as the cornerstone of a season- long program approach for weed management on crops with Enlist ® traits. Enlist ® herbicides control tough and herbicide- resistant weeds, including, but not limited to: Common ragweed

Marestail 3 Morningglory Waterhemp 3 Pigweed 3 (including Palmer amaranth 3 )

Giant ragweed Lambsquarters Velvetleaf

For a full listing of 90+ weeds controlled, reference the labels for Enlist Duo ® and Enlist One ® herbicides.

On-target characteristics of 2,4-D choline with Colex-D ® technology How Enlist herbicides differ from 2,4-D ester, amine and other traditional formulations: • Near-zero volatility — 2,4-D choline is 96% less volatile than 2,4-D ester. — 2,4-D choline is 88% less volatile than 2,4-D amine.

• Reduced physical drift potential • Better handling characteristics

Use the right application rate

Apply 4.75 pints of Enlist Duo ® herbicide or 2 pints of Enlist One ® herbicide per acre to young, actively growing weeds, according to the product label directions. 4 It’s essential to spray when weeds are 6 inches tall or less and to use the full herbicide rates. These practices help ensure best weed management and help prevent and mitigate the development of herbicide resistance.

Scan the QR code to find additional Product Use Guides.

3 May require a broader management plan including timely application and use of a soil residual herbicide. 4 Always read and follow the product label as well as state and local requirements.

Use Enlist ® herbicides as the cornerstone of your program approach

Key practices to remember: • Use full labeled rates for best weed management. • Spray when weeds are young, 6 inches tall or less. • Spray when weeds are actively growing. The product labels for Enlist Duo ® and Enlist One ® herbicides also contain important information about application equipment requirements, restrictions and precautions, and weed management.

You’ll have the greatest success in weed management if you use an Enlist ® herbicide as part of a program approach for weed control in Enlist ® crops. This improves weed control, reduces weed competition during key stages of crop growth and helps manage herbicide resistance.

POSTEMERGENCE APPLICATION RATE

Key items to remember: • Enlist ® herbicides can be used in burndown, preemergence and postemergence passes on crops with the Enlist ® trait. • Enlist herbicides are rainfast within four hours. • Up to three applications may be made per season (2 pt./A per application for Enlist One ® herbicide or 4.75 pt./A per application for Enlist Duo ® herbicide, where consistent with runoff management practices; see Page 28 for further information): — One application at burndown or preemergence — Up to two applications postemergence, at least 12 days apart • Always include a true broad-spectrum soil residual herbicide 6 in your weed management plan. • Consider using a layered residual, such as a Group 15 herbicide (e.g., acetochlor, S -metolachlor, pyraxasulfone), in your post passes for longer-lasting weed control.

Enlist Duo ® herbicide

4.75 pt./A

Enlist One ® herbicide

2 pt./A

Postemergence passes on Enlist ® acres

Enlist ® traits enable multiple options for postemergence herbicide sprays, allowing design of a program approach to fit each acre. Consider your weed pressure and agronomic situation when assessing which Enlist ® herbicide and tank-mix partners work best.

ENLIST ONE ® HERBICIDE + GLUFOSINATE

ENLIST ONE ® HERBICIDE + GLYPHOSATE

ENLIST DUO ® HERBICIDE

Enlist Duo herbicide @ 4.75 pt./A

Enlist One herbicide @ 2 pt./A

Ammonium sulfate (AMS) as needed

• Glufosinate @ 2 pt./A • 1.5 to 3 lb./A of AMS

• Glyphosate @ high rate • AMS as needed

Check EnlistTankMix.com for all qualified AMS and qualified glyphosate products. 5

5 Only products tested and found to not adversely affect spray drift properties of Enlist herbicides may be tank-mixed with Enlist herbicides. Listed products may be found at www.EnlistTankMix.com. Listing on website does not imply agronomic recommendation or endorsement of use. 6 Talk with your retailer for recommendations on preemergence and residual herbicides for your farm.

Herbicide partners help conquer tough weed challenges

Successful weed control means keeping weeds at bay throughout the growing season. The Enlist ® weed control system allows you to employ Enlist ® herbicides as the cornerstone of a program approach to overcome your toughest weed challenges. You also can incorporate preferred tank-mix partners and solutions from the industry-leading residual herbicide portfolio from Corteva Agriscience for season-long control.

The importance of residual herbicides

Residual herbicides play a critical role in keeping fields of Enlist E3 ® soybeans, Enlist ® corn and Enlist cotton clean. Using high-quality, overlapping soil residuals introduces different sites of action and helps keep weed pressure in check, setting you up for success when making postemergence applications that include an Enlist ® herbicide.

Preferred soybean residuals: Kyber ® Pro, Sonic ® Boom, Sonic ® , Enversa™ and Trivence ® herbicides Corteva soybean residual herbicides offer diverse sites of action and extended residual activity, and they fit very well into a program approach to protect Enlist E3 ® soybeans.

Scan the QR code to find the right soybean residual herbicides to protect your acres.

• Three sites of action: metribuzin, flumioxazin, pyroxasulfone • Application flexibility: Apply up to three days postplant • Each individual site of action in Kyber ® Pro herbicide is effective against difficult, herbicide-resistant weeds. Kyber ® Pro herbicide provides exceptional control of more than 50 broadleaf and grass weeds, including hard-to-control and ALS- and PPO-resistant weeds like Palmer amaranth and waterhemp. The new formulation also offers up to six weeks of residual activity.

Preemergence recommendation for Corn Belt states: Kyber ® Pro herbicide

• Two sites of action: metribuzin, sulfentrazone • Application flexibility: Apply up to three days postplant

• Sonic ® Boom herbicide comes in a convenient liquid premix for easy applications. Sonic ® Boom herbicide offers two powerful modes of action plus superior crop safety for clean fields and higher yield potential. This solution is especially effective against difficult, resistant broadleaves, including waterhemp, Palmer amaranth, marestail and kochia.

Preemergence recommendation for Corn Belt and Great Plains states: Sonic ® Boom herbicide

• Two sites of action: sulfentrazone, cloransulam • Application flexibility: Spray up to three days postplant • Works in a tank mix with Enlist Duo ® or Enlist One ® herbicide

Sonic ® herbicide is a trusted product that includes two sites of action, providing great residual efficacy on both large- and small-seeded broadleaf weeds as well as offering grass suppression. Plus, you get the flexibility to apply Sonic herbicide up to three days postplant.

Preemergence recommendation for Corn Belt and Great Plains states: Sonic ® herbicide

• Enversa™ herbicide is the residual tank-mix partner of choice for Enlist One ® herbicide. • Offers several weeks’ residual control of more than 25 broadleaf and grass weeds. • Labeled for use on multiple crops, including Enlist E3 ® soybeans, Enlist ® cotton and Enlist ® corn. Enversa™ herbicide is a propriety encapsulated acetochlor that, once applied, drives to the soil, which creates a protective residual barrier and provides excellent crop safety. The new solution also offers a wide application window — preplant up to R2 on soybeans and up to first bloom on cotton — to help navigate challenging weather conditions.

Postemergence recommendation for

soybean tank-mix residual with Enlist One ® herbicide: Enversa™ herbicide

• Three sites of action: chlorimuron, flumioxazin, metribuzin • Use for burndown and residual control

Trivence ® herbicide offers three sites of action to deliver reliable control of challenging broadleaf weeds in soybeans while helping preserve the efficacy of existing herbicide options. It’s effective against Palmer amaranth, marestail, waterhemp, giant ragweed, morningglory, common lambsquarters and more.

Preemergence recommendation for the Midsouth states, Kentucky,

Ohio and Michigan: Trivence ® herbicide

Preferred corn residuals: Resicore ® REV, Resicore ® and Kyro™ herbicides

Resicore ® REV, Resicore ® and Kyro™ herbicides each offer multiple sites of action, diverse sites of action and extended residual activity, and they fit very well into a program approach to protect Enlist ® corn.

• Three sites of action: acetochlor, mesotrione, clopyralid • Application flexibility: Spray on corn up to 24 inches tall

Resicore ® REV herbicide offers the proven, powerful weed control farmers have come to expect from Resicore ® herbicide in a new high-performance formulation that offers supercharged tank-mix compatibility and boosted crop safety. Plus, Resicore ® REV herbicide can be applied preplant, pre- or postemergence on corn up to 24 inches tall, providing the flexibility to handle application delays.

Preemergence recommendation for Corn Belt states: Resicore ® REV herbicide

• Three sites of action: acetochlor, mesotrione, clopyralid • Application flexibility: Spray on corn up to 11 inches tall

The three powerful sites of action in Resicore ® herbicide deliver long-lasting residual for excellent weed control on 75 of the toughest broadleaf and grass weeds, including Palmer amaranth, waterhemp and marestail. Resicore herbicide also has the flexibility to be used in a postemergence application and with glyphosate, atrazine and other corn herbicides.

Preemergence recommendation for Corn Belt, Great Plains and Midsouth states: Resicore ® herbicide

• Three sites of action: acetochlor, clopyralid, topramezone • Application flexibility: Spray on corn up to 24 inches tall • Works in a tank mix with Enlist One ® herbicide

Postemergence recommendation for Corn Belt, Great Plains and Midsouth states: Kyro™ herbicide

Kyro™ herbicide is a postemergence solution that combines three unique sites of action to control more than 65 troublesome broadleaf and grass weed varieties. This novel formulation is the first to offer acetochlor, clopyralid and topramezone together in one convenient premix, providing farmers another powerful option outside of glyphosate and ALS herbicides to control resistant grasses.

Scan the QR code to find the right corn residual herbicides to protect your acres.

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Save up to 10% on crop protection products from Corteva Agriscience

Choose from 100+ leading products, including Enlist ® herbicides and residual solutions

Save at the time of purchase, no waiting for rebates

Easily track and manage rewards online

With the TruChoice ® offer, you can save big on your crop protection purchases from Corteva Agriscience by funding a prepay account online or through a participating retailer. Scan the QR code to start saving now.

Tank-mixing Enlist One ® Herbicide With Glufosinate

The primary tank-mix recommendation with Enlist One ® herbicide is glufosinate for acres with high pressure of glyphosate-resistant broadleaf weeds , especially Palmer amaranth, waterhemp and kochia: • Most frequent tank-mix recommendation for the Cotton Belt, where higher levels of resistance and weed pressure are most prevalent • Combination of Enlist One herbicide + glufosinate provides multiple unique, effective sites of action on crops with the Enlist ® trait. 1 • Because of the inherent stability of 2,4-D choline, adding glufosinate in the tank with Enlist One herbicide does not increase the potential for volatility due to acidification.

OPTIMIZING A TANK MIX OF ENLIST ONE ® HERBICIDE + GLUFOSINATE ON ENLIST ® CROPS

Weed height Carrier volume

3 inches tall or less

20 GPA is recommended for best performance of glufosinate, especially when grasses or dense weeds are present; 15 GPA minimum required with tank mix of Enlist One herbicide + glufosinate. Use 1.5 to 3 lb./A of AMS. May be any combination of qualified dry AMS, liquid AMS or AMS-containing products found on EnlistTankMix.com. Use nozzle and corresponding spray pressure from the qualified list for Enlist One herbicide. Optimize coverage with qualified nozzles by using a less coarse nozzle with a higher operating pressure, such as an AIXR or an AITTJ60.

Adjuvants

Qualified nozzle selection

Know your rates: • Enlist One herbicide: 2 pt./A (32 fl. oz./A)

• Glufosinate: 2 pt/A (32 fl. oz./A). Please refer to label for rate details based on crop and crop timing, weed species, weed size, and weed density.

Weather at spray

Avoid low humidity and cloudy conditions to maximize efficacy of glufosinate.

Time of day Recommended spraying time is

APPLICATION WINDOW FOR GLUFOSINATE ON ENLIST ® CROPS

between 2 hours after dawn and 2 hours before sunset to maximize efficacy of glufosinate.

Enlist E3 ® soybeans

Up to the R1 growth stage

Wind speed Maximum 10 mph

Enlist ® corn 1

Up to V6 growth stage

Even these weeds don’t stand a chance:

PhytoGen ® Enlist ® cotton Up to early bloom or before 70 days prior to harvest

Waterhemp 4 Palmer amaranth 3

Waterhemp 3

Kochia 3

3 May require a broader management plan including timely application and use of a soil residual herbicide.

1 Non- Bt corn products with the Enlist ® trait may not contain glufosinate tolerance. See bag tag to verify herbicide tolerance.

Tank-mixing with Enlist ® herbicides

Begin with half-full tank of water carrier. Begin agitation and continue throughout mixing process. Add products one at a time, in the following order:

Applying an Enlist ® herbicide in a tank mix with other products The application window for an Enlist ® herbicide offers opportunities for tank mixes with other qualified products, such as other herbicides, insecticides, fungicides, micronutrients and adjuvants. Key items to remember: • A tank mix of an Enlist ® herbicide with other qualified herbicides provides multiple sites of action against tough weeds. Only use tank- mix partners listed on EnlistTankMix.com for every application of an Enlist herbicide. • For pigweed, waterhemp and kochia pressure,

6. Capsule suspension (CS) or suspension emulsion (SE)

1. AMS/water- conditioning agents

• Such as acetochlor in Enversa™ herbicide, a capsule suspension.

7. Emulsifiable concentrate (EC) • Such as S -metolachlor in EverpreX ® herbicide 8. Soluble liquids (SL) • Glyphosate products • Glufosinate products • Enlist Duo ® herbicide at 4.75 pt./A or Enlist One ® herbicide at 2 pt./A 9. Crop oil concentrate (COC), methylated seed oil (MSO), nonionic surfactant (NIS), other adjuvants

2. Preslurry water- soluble packets

3. Wettable powders/ dry flowables

4. Compatibility agents

5. Liquid flowables

10. Top off with water carrier

farmers should consider a tank mix of Enlist One ® herbicide + glufosinate.

Ammonium sulfate/water-conditioning agents The addition of an AMS or water-conditioning agent helps maintain optimum performance of glufosinate and glyphosate products tank-mixed with Enlist ® herbicides on annual and perennial weeds, particularly under hard water conditions or drought conditions. The addition of AMS products does not affect the inherently low-volatility characteristics of the 2,4-D choline in Enlist herbicides. The most current list of qualified AMS and water- conditioning agents is available at EnlistTankMix.com. Anti-foam/defoamers The addition of an anti-foaming agent is highly encouraged for ease of mixing and sprayer cleanout. The most current list of qualified anti-foam/defoamers is available at EnlistTankMix.com. ! Note on mixing with glyphosate products: When mixing with Enlist One ® herbicide, do not pour glyphosate products into the tank or inductor at the same time as Enlist One herbicide and do not allow concentrated products to come into contact. Add products one at a time, allowing enough time for recirculation between additions of each separate product. Failure to add products one at a time, lack of sufficient water during mixing or not allowing sufficient agitation may result in salting out.

• For heavy grass pressure and glyphosate- susceptible broadleaves, farmers can either use Enlist Duo ® herbicide, a convenient blend of 2,4-D choline and glyphosate, or Enlist One herbicide + glyphosate. • Layering residual herbicides as part of a tank mix with Enlist herbicides helps provide season-long control of tough broadleaf weeds and grasses. • Farmers and applicators can select from many qualified ammonium sulfate (AMS) products and defoamers, as well as many other adjuvant options, listed on EnlistTankMix.com.

Tank-mix sequence procedures Start with a clean sprayer before mixing a load with Enlist One ® or Enlist Duo ® herbicide.

Scan the QR code to download a tank-mix sequence fact sheet.

Check EnlistTankMix.com when planning your application.

Tank-mixing with grass herbicides When tank-mixing grass herbicides such as clethodim with Enlist One ® herbicide, increase the rate of the grass herbicide by a minimum of one-third to overcome potential antagonism. In addition, use recommended adjuvants for the grass herbicides. Do not exceed labeled rates with any recommended increase. To ensure the use of multiple sites of action for broadleaf control, include a broad-spectrum tank- mix partner or a sequential postemergence pass in your weed control program. Refer to all individual product labels, supplemental labeling and fact sheets for all products in the tank mixture, and observe all precautions and limitations on the labels, including application timing restrictions, soil restrictions, minimum plant-back interval and rotational guidelines. Use according to the most restrictive precautionary statements for each product in the tank mixture. In some cases, the addition of tank-mix products may cause increased crop response such as leaf speckling. Applications of emulsifiable concentrate products, or crop oils — including crop oil concentrates (COC), methylated seed oil concentrate (MSOC), high surfactant oil concentrates (HSOC) and vegetable- based oils — are more likely to result in a crop response.

QUALIFIED TANK-MIX PARTNERS ARE: ARE NOT:

• Tested for crop response

• Tested for physical tank-mix compatibility

Products that passed the U.S. Environmental Protection Agency (EPA)-mandated drift testing protocol, which is part of the conditions of registration for Enlist ® herbicides.

• An agronomic

recommendation

• An endorsement of any kind from Corteva Agriscience

• An indicator of performance

As part of the conditions of registration for Enlist ® herbicides, the EPA established a tank-mix testing protocol. One reason the drift testing protocol exists is to protect sensitive areas, where endangered species may have habitat, from spray drift. All qualified tank-mix products have passed established standards for spray performance. The most current list, which has the only tank-mix partners meeting the standards set by the EPA, is available at EnlistTankMix.com.

Scan the QR code to find qualified tank-mix partners for Enlist ® herbicides.

If you have further questions about proper handling and use of these products, or if you become aware of potential misuse or incidents involving these products, please contact Corteva Agriscience at 855-ENLIST1 (855-365-4781) .

Enlist Duo ® and Enlist One ® herbicides are the only 2,4-D products authorized for use with Enlist ® crops. Following burndown, use of unauthorized 2,4-D products that are not Enlist herbicides on crops with the Enlist ® trait is not permitted.

Selecting the right nozzles to optimize coverage and manage drift

The right nozzles can maximize product performance by managing the interaction between application volume, nozzle flow rate, nozzle type, operating pressure, ground speed, nozzle spacing and droplet size category.

Scan the QR code to find qualified nozzles for Enlist ® herbicides.

Key items to remember: • Use a qualified nozzle that provides the best possible coverage while appropriately managing spray droplets. • Use a minimum of 10 gallons of water carrier volume; 10 to 15 gallons recommended for Enlist ® herbicides. See Page 13 for information about tank-mixing Enlist One ® herbicide with glufosinate. • Take advantage of the flexibility provided by the listed nozzles and pressure ranges to select one that allows you to balance crop coverage and droplet size. • Only use nozzles and corresponding pressures listed on Enlist.com/Nozzles for every application of Enlist herbicides. 4

4 Always read and follow the product label as well as state and local requirements.

Field planning and application best management practices Start with field planning

Avoid downwind susceptible crops

An important part of stewardship with the Enlist weed control system is staying aware of your surroundings. It is especially important to protect susceptible crops and landscapes that have a high relative sensitivity to the 2,4-D choline in Enlist herbicides. Do not spray Enlist herbicides when the wind is blowing toward adjacent susceptible crops.

Field planning is being aware of your surroundings in terms of compatible crops and susceptible crops.

Good field planning is just good common sense; it’ll help maximize your success and the results of the Enlist ® weed control system. Prior to an application of an Enlist ® herbicide, carefully note the wind speed, wind direction, and the crops and landscape that are adjacent to the field you plan to spray. Watch wind direction during an application — be aware of shifting winds during your application. DO NOT SPRAY Enlist ® herbicides when wind is blowing toward adjacent susceptible crops.

DO NOT SPRAY SUSCEPTIBLE CROPS Cotton without Enlist ® trait Grapes Cucurbits Fruiting vegetables Tomatoes Tobacco

Scan the QR code to find the application guide for Enlist ® herbicides.

Know what’s around you

Be sure to find out what else is planted near your Enlist ® field before you spray. That information is crucial to a safe application of an Enlist ® herbicide that allows you to access all the advantages of the Enlist ® weed control system. For example, one advantage of having a compatible crop adjacent to an Enlist ® field is you may apply an Enlist ® herbicide when the wind is blowing within labeled wind speed range toward that compatible crop.

Check wind speed and direction

• Apply when wind speed is between 3 and 10 mph. Make sure to check with the state you are applying in as wind speed requirements may vary by state. Maximum wind speed on federal label of Enlist herbicides is 15 mph. • Always understand which crops and landscapes are downwind prior to making an application of an Enlist herbicide when deciding whether to spray or wait for better wind conditions. • Be aware of shifting winds during your application.

COMPATIBLE CROP EXAMPLES

All soybeans Corn

Wheat Alfalfa Rice Peanuts Sorghum

Controlling spray drift to improve on-target application To minimize the potential for herbicide drift, consider these factors when deciding when and how to apply an Enlist ® herbicide: • Be mindful that wind direction and wind speed are within label parameters. • Use only labeled nozzles and pressure ranges. • Avoid temperature inversions. For more information on temperature inversions, see Page 27. • Confirm the method of application is consistent with the label. Always read and follow the product label as well as state and local requirements related to application of pesticides. Apply an Enlist herbicide only with properly calibrated ground application equipment. Remember: Do not apply an Enlist ® herbicide under circumstances where spray drift may occur to food, forage or other plantings that might be damaged or rendered unfit for sale, use or consumption. Do not allow contact of the herbicide with foliage, green stems or exposed nonwoody roots of crops or desirable plants, including trees and cotton without the Enlist ® trait, because severe injury or destruction may result. Even small amounts of spray drift that may not be visible may injure susceptible broadleaf plants. Before making an application, please refer to your state’s sensitive-crop registry (if available) to identify any commercial specialty or certified organic crops that may be located nearby. At the time of your application, the wind cannot be blowing toward adjacent commercially grown tomatoes and other fruiting vegetables (both in EPA Crop Group 8), cucurbits including watermelon, pumpkin, squash and cucumbers (all in EPA Crop Group 9).

Know and follow federal, state and local requirements

Enlist Duo ® and Enlist One ® herbicides are not registered for sale or use in all states or counties. Contact your state pesticide regulatory agency to determine if a product is registered for sale or use in your area. When you apply an Enlist ® herbicide, you must follow all federal, state and local pesticide application requirements for Enlist Duo and/or Enlist One herbicides. Where states have more stringent regulations, they must be observed. Enlist Duo and Enlist One herbicides with Colex-D ® technology are the only herbicides containing 2,4-D that are authorized for preemergence and postemergence use on Enlist ® crops. 8 It is a federal offense to use any pesticide in a manner that results in an unauthorized “take” (e.g., kill or otherwise harm) of an endangered species or certain threatened species, under the Endangered Species Act Section 9. When using Enlist ® herbicides, you must follow the measures contained in the Endangered Species Protection Bulletin for the area you are applying the product. Before use of Enlist Duo and/or Enlist One herbicides, review the Restrictions section of the label to confirm that the county in which use is intended is not one where use is prohibited. In addition, obtain an Endangered Species bulletin for the intended use location no earlier than six months prior to the application and follow measures listed relevant to that location for the protection of endangered species. To obtain bulletins, consult the website www.epa.gov/espp, call 844-447-3813 or email espp@epa.gov. You must use the bulletin valid for the month in which you will apply the product. To report any ecological incidents, including mortality, injury or harm to nontarget plants or animals, call 855-ENLIST-1.

8 Enlist Duo ® and Enlist One ® herbicides have additional county restrictions in AL, GA, TN and TX. Contact your state pesticide regulatory agency to determine if a product is registered for sale or use in your area. Additional product-specific stewardship requirements for Enlist ® crops can be found at Enlist.com. Always read and follow label directions.

Field planning scenarios: Outside the Cotton Belt IS IT OK TO SPRAY ENLIST ONE ® OR ENLIST DUO ® HERBICIDE?

SOYBEANS WITHOUT THE ENLIST E3 ® TRAIT

If an adjacent susceptible crop is downwind, DO NOT SPRAY an Enlist ® herbicide. Use glufosinate and/or glyphosate to stay ahead of weeds if necessary. Buffer distances do not protect downwind adjacent susceptible crops. The best scenario is to wait until wind is blowing directly away from the vineyard, tomatoes or other susceptible crop.

Wind Direction 5 MPH

VINEYARD OR TOMATOES

ENLIST E3 ® SOYBEANS

CORN, WHEAT, ALFALFA OR SORGHUM

SOYBEANS WITHOUT THE ENLIST E3 ® TRAIT

Wind Direction 8 MPH

It’s OK to spray when wind is blowing away from susceptible crops and toward soybeans without the Enlist E3 ® trait. Soybeans without the Enlist E3 trait are not a susceptible crop, meaning you can spray when the wind is blowing toward them with no field separation.

VINEYARD OR TOMATOES

ENLIST E3 ® SOYBEANS

CORN, WHEAT, ALFALFA OR SORGHUM

It’s OK to spray and there are no wind directional restrictions when wind is blowing toward an adjacent compatible crop, such as corn, wheat, alfalfa or sorghum. Watch for shifting wind during the application. If wind shifts toward the susceptible crop, stop spraying.

SOYBEANS WITHOUT THE ENLIST E3 ® TRAIT

Wind Direction 5 MPH

VINEYARD OR TOMATOES

ENLIST E3 ® SOYBEANS

CORN, WHEAT, ALFALFA OR SORGHUM

Field planning scenarios: Inside the Cotton Belt IS IT OK TO SPRAY ENLIST ONE ® OR ENLIST DUO ® HERBICIDE?

SOYBEANS WITHOUT THE ENLIST E3 ® TRAIT

If an adjacent susceptible crop is downwind, DO NOT SPRAY an Enlist ® herbicide. Use glufosinate or glyphosate to stay ahead of weeds if necessary. Buffer distances do not protect downwind adjacent susceptible crops. The best scenario is to wait until wind is blowing directly away from the cotton without the Enlist ® trait.

Wind Direction 5 MPH

COTTON WITHOUT THE ENLIST ® TRAIT

ENLIST ® COTTON OR ENLIST E3 ® SOYBEANS

WHEAT, PEANUTS, SORGHUM OR RICE

SOYBEANS WITHOUT THE ENLIST E3 ® TRAIT

Wind Direction 8 MPH

It’s OK to spray when wind is blowing away from cotton without the Enlist trait and toward soybeans without the Enlist E3 ® trait. Soybeans without the Enlist E3 trait are not a susceptible crop, meaning you can spray when the wind is blowing toward them with no field separation.

COTTON WITHOUT THE ENLIST ® TRAIT

ENLIST ® COTTON OR ENLIST E3 ® SOYBEANS

WHEAT, PEANUTS, SORGHUM OR RICE

It’s OK to spray and there are no wind directional restrictions when wind is blowing toward an adjacent compatible crop, such as soybeans, corn, wheat, alfalfa, peanuts or rice. Watch for shifting wind during the application. If wind shifts toward the cotton without the Enlist trait, stop spraying.

SOYBEANS WITHOUT THE ENLIST E3 ® TRAIT

Wind Direction 10 MPH

ENLIST ® COTTON OR ENLIST E3 ® SOYBEANS

COTTON WITHOUT THE ENLIST ® TRAIT

WHEAT, PEANUTS, SORGHUM OR RICE

Avoiding temperature inversions

Protecting sensitive areas

A temperature inversion occurs when a layer of warm air covers a layer of cooler air and acts like a lid, preventing the cooler air from rising and dissipating into the upper atmosphere. During a temperature inversion, spray particles can become trapped in the warmer layer of air and stay suspended until wind movement increases, resulting in off-target movement. Never spray if you suspect a temperature inversion is present. You run the risk of damaging susceptible plants in nearby fields, lawns and gardens. Wait until later in the day and check again for a more favorable application environment. Before every application, use steps like these to make sure a temperature inversion is not occurring: • Monitor temperatures by using weather apps on your smartphone when planning an application and always check conditions in the field. If the temperature is within 5 degrees of the overnight low, closely check wind speed and particle movement in the field. • Measure wind speed by using an anemometer. If wind is less than 3 mph, do not spray. • Use smoke or powder to indicate particle movement. The smoke or powder should drift gently with the wind. If it gathers in a stationary, suspended cloud, that indicates a temperature inversion — do not spray. • Measure the temperature at ground level (approximately 3 feet) and at 7 feet above ground. If the difference is more than a few (3-4) degrees, it is considered an inversion.

The labels for Enlist One ® and Enlist Duo ® herbicides require a downwind buffer from sensitive areas, which may be a habitat for endangered species. To minimize the chance for an Enlist ® herbicide to come in contact with sensitive areas, you must maintain a 30-foot downwind buffer (in the direction in which the wind is blowing) from any area except: 1 Roads (paved or gravel surfaces) 2 Planted agricultural fields (except those crops mentioned in the susceptible crops section)

Agricultural fields that have been prepared for planting

4 Areas covered by the footprint of a building, feed crib or other man-made structure with walls and/ or roof To maintain the required downwind buffer zone, measure wind direction prior to the start of any swath that is within 30 feet of a sensitive area. No application swath can be initiated in or into an area that is within 30 feet of a sensitive area if the wind direction is toward the sensitive area.

WIND DIRECTION 30-FOOT BUFFER (IMPLEMENT WHEN WIND IS BLOWING TOWARD A SENSITIVE AREA)

NO BUFFER REQUIRED IF WIND IS BLOWING AWAY FROM SENSITIVE AREA

WIND DIRECTION

DO NOT SPRAY OVER BUFFER

OK TO SPRAY

APPLICATION AREA FOR ENLIST ® HERBICIDES

30-FOOT BUFFER

SENSITIVE AREA

APPLICATION AREA FOR ENLIST ® HERBICIDES

SENSITIVE AREA

DO NOT APPLY AN ENLIST ® HERBICIDE IF YOU SUSPECT A TEMPERATURE INVERSION

WARMER AIR

COOLER AIR

Implementing runoff management practices

MITIGATION MEASURES

CREDITS

3 applications

Reduce number of applications – reduced number of applications of Enlist ® herbicides per year. Applications may be made at any time during crop development but must maintain a minimum 12-day re-treatment interval.

Sound management of runoff benefits landowners, farmers and the environment. Land managers/ applicators must effectively implement mitigation measures that reduce, to the maximum extent practicable, runoff from treated fields. A variety of factors must be considered, including: • Application scheduling: – Do not apply this product when soil is saturated or at field capacity, or when a storm event likely to produce runoff from the treated area is forecast (by NOAA/National Weather Service, or other similar forecasting service) to occur within 48 hours following application. – Do not irrigate treated field within 48 hours of application. • Soil hydrologic grouping and corresponding mitigation measures – Users must know the soil hydrological type where application is occurring to implement required mitigation measures to prevent runoff. Soils are grouped into one of four categoies based on runoff potential; refer to the Enlist ® herbicide label for futher information about these hydrologic soil group (HSG) categories. – The required minimum criteria described for runoff mitigation measures are outlined at Enlist.com/MitigationMeasures. – The farmer/land manager will achieve mitigation measure “credits” toward the total required by implementing mitigation measures, such as using residue tillage; by managing field strips, buffers and neighboring vegetation; or by using contour farming, as shown in the table.

2 applications

1 application

Residue tillage management: no-till, strip-till, ridge-till and mulch-till

30-ft. off-field vegetative buffer on down slope

HSG A or B

HSG C or D

Vegetative filter strips

100-ft. off-field vegetative buffer on down slope

HSG A or B

HSG C or D

Field border: border with dense vegetative stands with a minimum width of 30 ft.

Cover crop

Vegetative barrier: Permanent strips of dense vegetation along the contours of the field with a minimum width of 3 ft.

Contour buffer strips or terrace

Grassed waterway

Water and sediment basin

Contour farming or contour stripcropping

To learn more, visit Enlist.com/MitigationMeasures or scan the QR code.

Completely drain the system (including pump, lines and spray boom) for at least five minutes. Fill the tank with clean water to at least 10% of the total tank volume. Circulate through the entire system for at least 15 minutes. Spray out the solution through the boom/nozzles.

RINSE 1

Completely drain the spray system (including lines and spray boom) for at least five minutes.

Cleanout and record keeping

RINSE 2

Clean out the sprayer and all spray equipment after applying an Enlist ® herbicide

Remove and clean the filters and strainers.

Fill the tank with clean water to at least 10% of total tank volume (including cleaning agents at recommended rates, if desired).

After applying an Enlist ® herbicide, be sure to clean out the sprayer before making your next application to any other crop. Thorough cleanout of the entire sprayer — including spray tank, boom, screens, filters, hoses and nozzles — is the first step to minimize the potential for sprayer contamination and damage to susceptible crops. Also, remember to keep other equipment, such as pumps, clean before switching to the next product. Follow the most stringent cleanout recommendation of any tank-mix partner included in the tank with an Enlist herbicide.

Circulate through the entire system for at least 15 minutes.

Let the solution stand for several hours, preferably overnight if time allows.

Spray out the solution through the boom/nozzles.

IF THE NEXT CROP YOU’RE SPRAYING IS GLYPHOSATE- TOLERANT CORN

TRIPLE-RINSE SPRAYER

Completely drain the spray system (including lines and boom) for at least five minutes. Fill the tank with clean water to at least 10% of the total tank volume. Circulate through the entire system for at least 15 minutes.

RINSE 3

Single-rinse sprayer with at least 10% of sprayer volume

As outlined in this Product Use Guide

Spray out the solution through the boom/nozzles.

Scan the QR code to find the full sprayer cleanout guide.

Completely drain the spray system; and remove and clean nozzle tips and strainers separately.

Record your application details As part of good farm management practices, maintain detailed records of spraying, including:

• Field location and number of acres sprayed • Crop sprayed and stage of growth • Date of application, start time and finish time • Application rates of herbicides sprayed and tank-mix partners • Nozzles used, operating pressure and boom height

• Travel speed and carrier volume • Air temperature and relative humidity

• Wind speed and direction • Sprayer and boom cleanout • Dates when reviewed labels and state/federal regulatory guidelines

Application summary Apply with confidence

Successful use of Enlist ® herbicides begins with proper application. Below is a summary of best management practices for applying an Enlist ® herbicide. Visit Enlist.com/Apply to download the application guide. Always read and follow label requirements.

BEFORE SPRAYING

PAY SPECIAL ATTENTION TO WIND AND WEATHER CONDITIONS

Application window Apply Enlist ® herbicides within the appropriate growth stage windows. Enlist ® cotton: No later than first white bloom Enlist E3 ® soybeans: Through R1 growth stage Enlist ® corn: No larger than V8 growth stage or 30 inches tall, whichever happens first • Unless applying with drop nozzles, then may spray up to 48 inches tall Tank-mix partners Use multiple, effective sites of action, including partner herbicides. Follow the correct tank-mix sequence as detailed on the label. Glufosinate: Tank-mix Enlist One ® herbicide with a qualified glufosinate herbicide for the toughest broadleaves. Glyphosate herbicides: Tank-mix Enlist One Nozzles Select the best qualified nozzle and pressure that optimizes coverage for your application scenario. View the full list of nozzles for use with Enlist herbicides at Enlist.com/Nozzles. Sprayer contamination Clean your sprayer before using Enlist herbicides to avoid contamination from a prior application. herbicide with a qualified glyphosate herbicide for grasses and glyphosate- susceptible broadleaves

Wind speed, weather Wind speed: Drift potential is lowest at wind speeds less than 10 mph. Target applications at wind speeds greater than 3 mph but less than 10 mph. Caution: Do not apply at wind speeds greater than 15 mph. Consult: Some states have additional restrictions on wind speed. Check your state regulations on wind speed. Temperature inversions: Do not spray during a temperature inversion. Caution: Inversions are more common between dusk and dawn. Susceptible crops Spray when wind is blowing away from susceptible crops listed on the Enlist ® herbicide labels. This includes: tomatoes, fruiting vegetables, cucurbits, grapes, cotton without the Enlist ® trait and tobacco. Caution: There is no acceptable buffer distance when the wind is blowing toward an adjacent susceptible crop. DO NOT SPRAY if wind is blowing toward a susceptible crop.

APPLICATION

Spray volume Use a spray volume of 10 to 15 gallons or more per acre and apply with calibrated ground equipment. Do not apply less than 10 gallons of total spray volume per acre. In general, increase spray volume as crop canopy, height and weed density increase to obtain adequate spray coverage. 3 Special note on tank mix of Enlist One ® + glufosinate: Use a spray volume of 15 to 20 gallons per acre. Do not apply less than 15 gallons of total spray volume per acre. Spray rate Use spray rates from the product labels when weeds are shorter than 6 inches and crops are within the appropriate growth stage window. Enlist Duo ® herbicide: Spray 4.75 pt./A. Enlist One herbicide: Spray 2 pt./A. Spray pressure Use an appropriate spray pressure within the qualified range for optimum coverage. Spraying at the higher end of the labeled psi will provide better coverage. Ground speed, product volume and nozzle selection all factor into the appropriate spray pressure.

Boom height To minimize spray drift potential, maintain a boom height as specified by the nozzle manufacturer, usually 24 inches or less above crop canopy. 4

AFTER SPRAYING

Cleanout After applying an Enlist ® herbicide, follow the proper steps to clean out your sprayer. Triple-rinse is required for all cleanouts unless the next crop you are spraying is glyphosate-resistant corn.

Scan the QR code to find the full application guide for Enlist ® herbicides.

3 May require a broader management plan including timely application and use of a soil residual herbicide. 4 Always read and follow the product label as well as state and local requirements.

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